Hematopoiesis & Immunity
Our laboratory is interested in the development of the blood-forming, or hematopoietic, system in the vertebrate embryo. Most of our studies are aimed at understanding how the hematolymphoid system arises in the zebrafish embryo from the first hematopoietic stem cells. We are utilizing the many advantages that the zebrafish system offers to study the ontogeny of hematopoiesis and immunity. These include the easy visualization of blood cells in the translucent embryo and the ability to dissect genetically the pathways important for blood cell specification, maintenance and function.
- Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms.
- Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.
- Direct Visualization of Live Zebrafish Glycans via Single-Step Metabolic Labeling with Fluorophore-Tagged Nucleotide Sugars.
- EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells.
- Embryonic Immune Cells Remodel the Heart.
- AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate.
- Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos.
- Zebrafish snai2 mutants fail to phenocopy morphant phenotypes.
- Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish.
- Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.