Hematopoiesis & Immunity
Our laboratory is interested in the development of the blood-forming, or hematopoietic, system in the vertebrate embryo. Most of our studies are aimed at understanding how the hematolymphoid system arises in the zebrafish embryo from the first hematopoietic stem cells. We are utilizing the many advantages that the zebrafish system offers to study the ontogeny of hematopoiesis and immunity. These include the easy visualization of blood cells in the translucent embryo and the ability to dissect genetically the pathways important for blood cell specification, maintenance and function.
- Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.
- Wnt Signaling in Hematological Malignancies.
- WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development.
- Endocardial infarct scar recognition by myocardial electrical impedance is not influenced by changes in cardiac activation sequence.
- Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.
- Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence.
- The role of Wnt signaling in hematopoietic stem cell development.
- The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.
- Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis.
- Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.