Hematopoiesis & Immunity
Our laboratory is interested in the development of the blood-forming, or hematopoietic, system in the vertebrate embryo. Most of our studies are aimed at understanding how the hematolymphoid system arises in the zebrafish embryo from the first hematopoietic stem cells. We are utilizing the many advantages that the zebrafish system offers to study the ontogeny of hematopoiesis and immunity. These include the easy visualization of blood cells in the translucent embryo and the ability to dissect genetically the pathways important for blood cell specification, maintenance and function.
- The role of Wnt signaling in hematopoietic stem cell development.
- The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.
- Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis.
- Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.
- A Four-Well Dish for High-Resolution Longitudinal Imaging of the Tail and Posterior Trunk of Larval Zebrafish.
- Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.
- Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes.
- Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.
- CRISPR Guide RNA Validation In Vitro.
- Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.